Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Eur J Anaesthesiol. 1988 Sep;5(5):313-21.

Comparison between epidural fentanyl, sufentanil, carfentanil, lofentanil and alfentanil in the rat: analgesia and other in vivo effects.

Author information

  • 1Janssen Research Foundation, Department of Neuropsychopharmacology, Beerse, Belgium.

Abstract

The effects of epidural fentanyl, sufentanil, carfentanil, lofentanil and alfentanil were compared in the rat. All five opiates produced analgesia with the relative order of potency being lofentanil greater than carfentanil greater than sufentanil greater than fentanyl greater than alfentanil, and the relative order of duration at comparative doses lofentanil greater than sufentanil greater than carfentanil greater than fentanyl greater than alfentanil. Because epidural administered opiates still exert some effects within the brain, specificity ratios (defined as the ratio between the ED50s for a prolongation of the tail-withdrawal reaction latency and a blockade of the pinna reflex) were calculated. The relative order of specificity between the five opiates was fentanyl greater than lofentanil greater than sufentanil greater than carfentanil greater than alfentanil. These results are discussed in the context of the search for a safe and sufficiently long-acting lipid soluble epidural analgesic. It is concluded that of these five opiates, sufentanil appears to be the best drug of choice for epidural analgesia.

PMID:
2905988
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk