Quantitation of Surface Coating on Nanoparticles Using Thermogravimetric Analysis

Alpana A Dongargaonkar; Jeffrey D Clogston

doi:10.1007/978-1-4939-7352-1_6

Quantitation of Surface Coating on Nanoparticles Using Thermogravimetric Analysis

Methods Mol Biol. 2018:1682:57-63. doi: 10.1007/978-1-4939-7352-1_6.

Authors

Alpana A Dongargaonkar¹, Jeffrey D Clogston²

Affiliations

¹ Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, P.O. Box B, Frederick, MD, 21702, USA.
² Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, P.O. Box B, Frederick, MD, 21702, USA. Jeffrey.Clogston@fnlcr.nih.gov.

PMID: 29039093
DOI: 10.1007/978-1-4939-7352-1_6

Abstract

Nanoparticles are critical components in nanomedicine and nanotherapeutic applications. Some nanoparticles, such as metallic nanoparticles, consist of a surface coating or surface modification to aid in its dispersion and stability. This surface coating may affect the behavior of nanoparticles in a biological environment, thus it is important to measure. Thermogravimetric analysis (TGA) can be used to determine the amount of coating on the surface of the nanoparticle. TGA experiments run under inert atmosphere can also be used to determine residual metal content present in the sample. In this chapter, the TGA technique and experimental method are described.

Keywords: Colloidal metal nanoparticles; Inorganic nanoparticles; Nanoparticles; Surface coating; TGA.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Coated Materials, Biocompatible / chemistry*
Nanoparticles / chemistry*
Nanotechnology / methods
Surface Properties
Thermogravimetry / methods*

Substances

Coated Materials, Biocompatible

Grants and funding

HHSN261200800001E/CA/NCI NIH HHS/United States