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Science. 1988 Nov 4;242(4879):715-23.

Cellular and molecular mechanisms of drug dependence.

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  • 1Research Institute of Scripps Clinic, La Jolla, CA 92037.


The molecular and cellular actions of three classes of abused drugs--opiates, psychostimulants, and ethanol--are reviewed in the context of behavioral studies of drug dependence. The immediate effects of drugs are compared to those observed after long-term exposure. A neurobiological basis for drug dependence is proposed from the linkage between the cellular and behavioral effects of these drugs.

[PubMed - indexed for MEDLINE]
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