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Sci Am. 1988 Feb;258(2):40-8.

Chromosome mapping with DNA markers.

Abstract

New markers called RFLP's (for restriction-fragment length polymorphisms) can indicate the location on a chromosome of a disease-causing gene and serve to identify carriers. With enough markers one can map the human chromosomes--the first step toward an ambitious goal of molecular biology: sequencing the entire human genome.

PMID:
2903549
[PubMed - indexed for MEDLINE]
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