-
Zacopride, a potent 5-HT3 antagonist.
Department of Pharmacology, A. H. Robins Co., Richmond, VA 23220.
The substituted benzamide derivative zacopride was found to antagonize competitively the effects of 5-hydroxytryptamine (5-HT) on the guinea-pig ileum, the rabbit vagus nerve and the von Bezold Jarisch reflex in the rat. The potency of zacopride was comparable with that of ICS 205-930 and it is concluded that zacopride possesses 5-HT3 receptor antagonizing properties.
PMID: 2900319 [PubMed - indexed for MEDLINE]
-
Cited by 7 PubMed Central articles
-
The enantiomers of zacopride: an intra-species comparison of their potencies in functional and anxiolytic models.
Bill DJ, Coleman J, Hallett I, Middlefell VC, Rhodes KF, Fletcher A.
Br J Pharmacol. 1995 Jul; 115(5):775-80.
[Br J Pharmacol. 1995]
-
5-HT4 receptor mediated facilitation of the emptying phase of the peristaltic reflex in the guinea-pig isolated ileum.
Costall B, Naylor RJ, Tuladhar BR.
Br J Pharmacol. 1993 Dec; 110(4):1572-8.
[Br J Pharmacol. 1993]
-
Characterization of 5-HT3 and 'atypical' 5-HT receptors mediating guinea-pig ileal contractions in vitro.
Eglen RM, Swank SR, Walsh LK, Whiting RL.
Br J Pharmacol. 1990 Nov; 101(3):513-20.
[Br J Pharmacol. 1990]
- » See all...