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    J Pharm Pharmacol. 1988 Apr;40(4):301-2.

    Zacopride, a potent 5-HT3 antagonist.

    Smith WW, Sancilio LF, Owera-Atepo JB, Naylor RJ, Lambert L.

    Department of Pharmacology, A. H. Robins Co., Richmond, VA 23220.

    The substituted benzamide derivative zacopride was found to antagonize competitively the effects of 5-hydroxytryptamine (5-HT) on the guinea-pig ileum, the rabbit vagus nerve and the von Bezold Jarisch reflex in the rat. The potency of zacopride was comparable with that of ICS 205-930 and it is concluded that zacopride possesses 5-HT3 receptor antagonizing properties.

    PMID: 2900319 [PubMed - indexed for MEDLINE]

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