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Arzneimittelforschung. 1988 Apr;38(4):561-2.

Effect of food on absorption of chlordemethyldiazepam.

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  • 1Department of Pharmacology and Clinical Neurology, Istituto Scientifico San Raffaele, Universita' degli Studi, Milan, Italy.


The kinetics of a single 1-mg oral dose of chlordemethyldiazepam (CDDZ, En) was determined on two occasions in 8 healthy volunteers. CDDZ was given in the fasting state on one occasion and following a standard meal on another. Compared with the fasting state, administration of CDDZ with food prolonged the time to reach peak concentration (1.5 vs. 6.8 h after dosage, p less than 0.01) and the absorption half-life (28 vs. 231 min, p less than 0.01). Total area under the curve was not influenced, nor was CDDZ elimination half-life (84.2 vs. 88.7 h). Thus administration of CDDZ with food slows the rate of its absorption but does not alter the completeness of absorption.

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