Comparison of the Guidelines of the Clinical Pharmacogenetics Implementation Consortium and the Dutch Pharmacogenetics Working Group

Clin Pharmacol Ther. 2018 Apr;103(4):599-618. doi: 10.1002/cpt.762. Epub 2017 Oct 10.

Abstract

Both the Clinical Pharmacogenetics Implementation Consortium (CPIC) and Dutch Pharmacogenetics Working Group provide therapeutic recommendations for well-known gene-drug pairs. Published recommendations show a high rate of concordance. However, as a result of different guideline development methods used by these two consortia, differences between the published guidelines exist. The aim of this paper is to compare both initiatives and explore these differences, with the objective to achieve harmonization.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Genetic Testing / methods
  • Humans
  • Netherlands
  • Pharmacogenetics* / methods
  • Pharmacogenetics* / standards
  • Practice Guidelines as Topic*
  • Practice Patterns, Physicians'
  • Precision Medicine* / methods
  • Precision Medicine* / standards
  • Translational Research, Biomedical / methods
  • Translational Research, Biomedical / standards
  • United States