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Science. 1988 Jul 1;241(4861):58-62.

Purification and characterization of mouse hematopoietic stem cells.

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  • 1Department of Pathology, Stanford University School of Medicine, CA 94305.

Erratum in

  • Science 1989 Jun 2;244(4908):1030.


Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers. These cells can proliferate and differentiate with approximately unit efficiency into myelomonocytic cells, B cells, or T cells. Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors.

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