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Jpn J Pharmacol. 1988 Mar;46(3):311-4.

Interaction of SM-3997 with serotonin receptors in rat brain.

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  • 1Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd., Osaka, Japan.


The propensity of SM-3997 to displace 3H-ligands was tested in vitro in a number of receptor-binding assays. SM-3997 possessed a high affinity towards 5-HT1A receptors, low affinity towards dopamine (D2) and 5-HT2 receptors, and no affinity towards benzodiazepine (BZ), GABA, 5-HT1B and adrenergic receptors. Moreover, SM-3997 facilitated neither 3H-flunitrazepam binding nor 3H-muscimol binding. These results suggest that the action of SM-3997 may be mediated via central 5-HT1A receptors but not the BZ-GABA receptor complex.

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