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1: Eur J Pharmacol. 1988 Jan 5;145(1):75-80.Links

Can benzodiazepines be classified by characterising their anticonvulsant tolerance-inducing potential?

Garratt JC, Gent JP, Feely M, Haigh JR.

Department of Pharmacology, University of Leeds, U.K.

The development of anticonvulsant tolerance with three benzodiazepines was assessed in mice using a slow intravenous infusion of pentylenetetrazol as the convulsive stimulus. Chlordiazepoxide (12.5 mg/kg b.d.) and midazolam (0.75 mg/kg b.d.) induced a slowly evolving tolerance over 15 days whereas nitrazepam (0.6 mg/kg b.d.) induced a very marked rapid tolerance which developed no further during 6 days treatment. Tolerance appeared to be incomplete with all three benzodiazepines. Possible explanations for the differences in tolerance profile are discussed and an alternative basis for the classification of benzodiazepines is suggested.

PMID: 2894998 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Chlordiazepoxide (Librium® , Limbitrol® , Limbitrol® DS)

    Chlordiazepoxide is used to relieve anxiety and to control agitation caused by alcohol withdrawal.

  • Midazolam (available generically)

    Midazolam is given to children before medical procedures or before anesthesia for surgery to cause drowsiness, relieve anxiety, and prevent any memory of the event. Midazolam is in a class of medications called benzodiaz...

  • Source: AHFS Consumer Medication Information