Purification and characterization of a growth inhibitory hepatic peptide. A preliminary note

Virchows Arch B Cell Pathol Incl Mol Pathol. 1987;54(3):152-4. doi: 10.1007/BF02899207.

Abstract

A pentapeptide isolated from normal mouse liver seems to inhibit DNA synthesis (3H-thymidine incorporation into liver DNA and labeling indices) and the mitotic rate (G2-M cell flux) in regenerating mouse liver. The inhibitor is somewhat similar to the growth inhibitory pentapeptides previously reported for granulocytes and epidermis. It is active at very low dose levels, showing a bell-shaped dose-response curve.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA / biosynthesis
  • DNA / drug effects
  • Growth Inhibitors / isolation & purification*
  • Growth Inhibitors / pharmacology
  • Hepatectomy
  • Liver / analysis*
  • Liver / cytology
  • Liver Regeneration / drug effects
  • Mice
  • Mice, Hairless
  • Mitosis / drug effects

Substances

  • Growth Inhibitors
  • DNA