J Neurochem. 1988 Mar;50(3):988-91.

Analysis of the 5' region of the human tyrosine hydroxylase gene: combinatorial patterns of exon splicing generate multiple regulated tyrosine hydroxylase isoforms.

Le Bourdellès B, Boularand S, Boni C, Horellou P, Dumas S, Grima B, Mallet J.

Source

Laboratoire de Neurobiologie Cellulaire et Moléculaire, CNRS, Gif sur Yvette, France.

Abstract

A single human gene has been described to encode multiple tyrosine hydroxylase (TH) mRNAs. The study of this variation has been extended by S1 mapping experiments and by analysis of the 5' region of the TH gene. Four different mRNAs were found to originate solely from alternative splicing of two exons. Comparison of the 5' flanking regions of human and rat genes discloses several highly conserved segments, likely to play an important role in the regulation of TH gene expression.

PMID:: 2892893; [PubMed - indexed for MEDLINE]

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TH Gene - Genetics Home Reference

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Related citations in PubMed

Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types. [J Biochem. 1988]
Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types.
Kobayashi K, Kaneda N, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T. J Biochem. 1988 Jun; 103(6):907-12.
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Coker GT 3rd, Vinnedge L, O'Malley KL. Biochem Biophys Res Commun. 1988 Dec 30; 157(3):1341-7.
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Review The human tyrosine hydroxylase gene.
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Review Tyrosine hydroxylase: human isoforms, structure and regulation in physiology and pathology. [Essays Biochem. 1995]
Review Tyrosine hydroxylase: human isoforms, structure and regulation in physiology and pathology.
Nagatsu T. Essays Biochem. 1995; 30:15-35.

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Cited by 2 PubMed Central articles

Retroviral transfer of a human tyrosine hydroxylase cDNA in various cell lines: regulated release of dopamine in mouse anterior pituitary AtT-20 cells. [Proc Natl Acad Sci U S A. 1989]
Retroviral transfer of a human tyrosine hydroxylase cDNA in various cell lines: regulated release of dopamine in mouse anterior pituitary AtT-20 cells.
Horellou P, Guibert B, Leviel V, Mallet J. Proc Natl Acad Sci U S A. 1989 Sep; 86(18):7233-7.
Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro. [Biochem J. 1990]
Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro.
Manser E, Fernandez D, Loo L, Goh PY, Monfries C, Hall C, Lim L. Biochem J. 1990 Apr 15; 267(2):517-25.

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