Lancet. 1987 Dec 19;2(8573):1431-3.

Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense sleeping sickness.

Pepin J, Milord F, Guern C, Schechter PJ.

Source

University of Sherbrooke, Canada.

Abstract

26 patients with arseno-resistant Trypanosoma brucei gambiense trypanosomiasis were treated with difluoromethylornithine (eflornithine), an inhibitor of ornithine decarboxylase, given intravenously, then orally. There was rapid disappearance of trypanosomes in the cerebrospinal fluid (CSF), gradual decrease of CSF lymphocytosis, and parallel improvement in central nervous system status. Side-effects, including diarrhoea, anaemia, and hair loss, were common but tolerable and reversible. 5 patients died during or shortly after treatment. None of the 21 patients who completed therapy has had a relapse during the 6-30 month follow-up.

PMID:: 2891995; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Elsevier Science

Molecular Biology Databases

ARSENIC COMPOUNDS - HSDB

Supplemental Content

Related citations

Efficacy and toxicity of eflornithine for treatment of Trypanosoma brucei gambiense sleeping sickness. [Lancet. 1992]
Efficacy and toxicity of eflornithine for treatment of Trypanosoma brucei gambiense sleeping sickness.
Milord F, Pépin J, Loko L, Ethier L, Mpia B. Lancet. 1992 Sep 12; 340(8820):652-5.
[A trial treatment with eflornithine of trypanosomiasis caused by Trypanosoma brucei gambiense in the Peoples Republic of the Congo]. [Med Trop (Mars). 1989]
[A trial treatment with eflornithine of trypanosomiasis caused by Trypanosoma brucei gambiense in the Peoples Republic of the Congo].
Eozenou P, Jannin J, Ngampo S, Carme B, Tell GP, Schechter PJ. Med Trop (Mars). 1989 Apr-Jun; 49(2):149-54.
Treatment of human late stage gambiense trypanosomiasis with alpha-difluoromethylornithine (eflornithine): efficacy and tolerance in 14 cases in Côte d'Ivoire. [Am J Trop Med Hyg. 1987]
Treatment of human late stage gambiense trypanosomiasis with alpha-difluoromethylornithine (eflornithine): efficacy and tolerance in 14 cases in Côte d'Ivoire.
Doua F, Boa FY, Schechter PJ, Miézan TW, Diai D, Sanon SR, De Raadt P, Haegele KD, Sjoerdsma A, Konian K. Am J Trop Med Hyg. 1987 Nov; 37(3):525-33.
Review Eflornithine for the treatment of human African trypanosomiasis. [Parasitol Res. 2003]
Review Eflornithine for the treatment of human African trypanosomiasis.
Burri C, Brun R. Parasitol Res. 2003 Jun; 90 Supp 1:S49-52. Epub 2002 Dec 10.
Review Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis. [Parasitol Res. 2003]
Review Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis.
Nok AJ. Parasitol Res. 2003 May; 90(1):71-9. Epub 2003 Jan 31.

See reviews... See all...

Cited by 4 PubMed Central articles

Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6. [Mol Biochem Parasitol. 2011]
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6.
Baker N, Alsford S, Horn D. Mol Biochem Parasitol. 2011 Mar; 176(1):55-7. Epub 2010 Nov 18.
A high-affinity putrescine-cadaverine transporter from Trypanosoma cruzi. [Mol Microbiol. 2010]
A high-affinity putrescine-cadaverine transporter from Trypanosoma cruzi.
Hasne MP, Coppens I, Soysa R, Ullman B. Mol Microbiol. 2010 Apr; 76(1):78-91. Epub 2010 Feb 10.
Review Human antiprotozoal therapy: past, present, and future. [Clin Microbiol Rev. 1995]
Review Human antiprotozoal therapy: past, present, and future.
Khaw M, Panosian CB. Clin Microbiol Rev. 1995 Jul; 8(3):427-39.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense sleepi...
Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense sleeping sickness.
Lancet. 1987 Dec 19 ;2(8573):1431-3.

PubMed
An unusual staged labial rejuvenation.
An unusual staged labial rejuvenation.
J Sex Med. 2008 May ;5(5):1263-7; discussion 1263-7. Epub 2008 Mar 4 .

PubMed
Labia majora hypertrophy.
Labia majora hypertrophy.
Aesthetic Plast Surg. 2009 Nov ;33(6):859-63.

PubMed
Prostate mechanical imaging: a new method for prostate assessment.
Prostate mechanical imaging: a new method for prostate assessment.
Urology. 2008 Mar ;71(3):425-9.

PubMed
Amoxycillin/clavulanic acid (augmentin) compared with triple drug therapy for pe...
Amoxycillin/clavulanic acid (augmentin) compared with triple drug therapy for pelvic inflammatory disease.
Int J Gynaecol Obstet. 1992 May ;38(1):41-3.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense sleeping sickness.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 4 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information