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Am J Hum Genet. 1987 Nov;41(5):944-7.

Linkage of DNA probe B79a (D7S13) to cystic fibrosis.

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  • 1Department of Biochemistry, St. Mary's Hospital Medical School, University of London, England.

Abstract

We have conducted, in 64 affected families, a study of linkage between the anonymous DNA segment pB79a (D7S13) and the locus for cystic fibrosis (CF) on chromosome 7q. The maximum lod score was 12.60 at theta = .08 (confidence bounds .045-.135). Although D7S13 is not sufficiently close to CF for routine use in DNA-based prenatal diagnosis, it will be helpful in certain families when other nearby markers are uninformative. D7S13 will also be useful for refining the linkage map of the CF region.

PMID:
2890297
[PubMed - indexed for MEDLINE]
PMCID:
PMC1684343
Free PMC Article
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