Use of fibrinogen and thrombin sponge in pediatric split liver transplantation

Acta Cir Bras. 2017 Aug;32(8):673-679. doi: 10.1590/s0102-865020170080000009.

Abstract

Purpose:: To analyze the use of this sponge in pediatric patients undergoing split-liver transplantation.

Methods:: Retrospective study, including 35 pediatric patients undergoing split-liver transplantation, divided into two groups according to the use of the sponge: 18 patients in Group A (no sponge) and 17 in Group B (with sponge).

Results:: The characteristics of recipients and donors were similar. We observed greater number of reoperation due to bleeding in the wound area in Group A (10 patients - 55.5%) than in Group B (3 patients - 17.6%); p = 0.035. The median volume of red blood cells transfused in Group A was significantly higher (73.4 ± 102.38 mL/kg) than that in Group B (35.1 ± 41.67 mL/kg); p = 0.048. Regarding bile leak there was no statistical difference.

Conclusion:: The use of the human fibrinogen and thrombin sponge, required lower volume of red blood cell transfusion and presented lower reoperation rates due to bleeding in the wound area.

MeSH terms

  • Blood Loss, Surgical / prevention & control
  • Erythrocyte Transfusion
  • Female
  • Fibrinogen / therapeutic use*
  • Hemostasis, Surgical / methods*
  • Hemostatics / therapeutic use*
  • Hepatectomy / methods
  • Humans
  • Infant
  • Liver / surgery
  • Liver Transplantation / adverse effects
  • Liver Transplantation / methods*
  • Male
  • Reoperation
  • Reproducibility of Results
  • Retrospective Studies
  • Statistics, Nonparametric
  • Surgical Sponges*
  • Surgical Wound / drug therapy
  • Thrombin / therapeutic use*
  • Treatment Outcome

Substances

  • Hemostatics
  • Fibrinogen
  • Thrombin