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Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age.
Department of Medicine, Western General Hospital, Edinburgh.
The sodium retention associated with liquorice ingestion has been thought to be due to a direct mineralocorticoid effect, despite the fact that it does not seem to occur in patients or animals with severe adrenal insufficiency. This study in seven normal subjects given liquorice showed that sodium retention is associated with a significant change in cortisol metabolism indicating inhibition of 11-beta-hydroxysteroid dehydrogenase (11 beta-OHSD). Congenital deficiency of this enzyme produces a syndrome of apparent mineralocorticoid excess. It is suggested that in both conditions there is a defect in the renal conversion of cortisol to cortisone by 11 beta-OHSD which results in high intrarenal cortisol levels, acting on type 1 mineralocorticoid receptors to cause sodium retention.
PMID: 2889032 [PubMed - indexed for MEDLINE]
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Cited by 9 PubMed Central articles
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A switch in the mechanism of hypertension in the syndrome of apparent mineralocorticoid excess.
Bailey MA, Paterson JM, Hadoke PW, Wrobel N, Bellamy CO, Brownstein DG, Seckl JR, Mullins JJ.
J Am Soc Nephrol. 2008 Jan; 19(1):47-58. Epub 2007 Nov 21.
[J Am Soc Nephrol. 2008]
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Reduced activity of 11 beta-hydroxysteroid dehydrogenase in patients with cholestasis.
Quattropani C, Vogt B, Odermatt A, Dick B, Frey BM, Frey FJ.
J Clin Invest. 2001 Nov; 108(9):1299-305.
[J Clin Invest. 2001]
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Steroid disorders in children: congenital adrenal hyperplasia and apparent mineralocorticoid excess.
New MI, Wilson RC.
Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12790-7.
[Proc Natl Acad Sci U S A. 1999]
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Patient Drug Information
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Potassium (Glu-K® , K+ 10® , K+ 8® , ...)
Potassium is essential for the proper functioning of the heart, kidneys, muscles, nerves, and digestive system. Usually the food you eat supplies all of the potassium you need. However, certain diseases (e.g., kidney dis...