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DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11.
A human genomic DNA fragment in phage lambda containing FSHB, the gene for the beta-subunit of human follicle-stimulating hormone (FSH-beta), was analyzed and the nucleotide sequence of the region of the clone encoding FSH-beta was determined. A subclone of the lambda phage containing 67% of FSH-beta coding sequence was used as hybridization probe to determine the human chromosomal location of FSHB. A panel of mouse-human somatic cell hybrids containing reduced numbers of human chromosomes was screened with the FSHB probe; complete cosegregation of FSHB with human chromosome 11 was observed in all 26 cell hybrids tested. Analysis of a set of cell hybrids containing translocated derivatives of chromosome 11 further localized FSHB to the human chromosome region 11p11.2----11pter. A Hind III restriction fragment length polymorphism (RFLP) detected by another subclone of the lambda phage containing FSHB now provides a genetic marker for this region of the human genome.
PMID: 2885163 [PubMed - indexed for MEDLINE]
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Cited by 8 PubMed Central articles
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Haplotype structure of FSHB, the beta-subunit gene for fertility-associated follicle-stimulating hormone: possible influence of balancing selection.
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[Ann Hum Genet. 2007]
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Loss of allelic heterozygosity at a second locus on chromosome 11 in sporadic Wilms' tumor cells.
Reeve AE, Sih SA, Raizis AM, Feinberg AP.
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[Mol Cell Biol. 1989]
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Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5.
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Am J Hum Genet. 1989 May; 44(5):711-9.
[Am J Hum Genet. 1989]
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