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The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro.
Cell-free extracts prepared from human 293 cells, supplemented with purified SV40 large-T antigen, support replication of plasmids containing the SV40 origin of DNA replication. A cellular protein (Mr approximately 36,000) that is required for efficient SV40 DNA synthesis in vitro has been purified from these extracts. This protein is recognized by human autoantibodies and is identified as the cell-cycle regulated protein known as proliferating cell nuclear antigen (PCNA) or cyclin.
PMID: 2882422 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis.
Haracska L, Unk I, Prakash L, Prakash S.
Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6477-82. Epub 2006 Apr 12.
[Proc Natl Acad Sci U S A. 2006]
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Evolutionary clues to eukaryotic DNA clamp-loading mechanisms: analysis of the functional constraints imposed on replication factor C AAA+ ATPases.
Neuwald AF.
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[Nucleic Acids Res. 2005]
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Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design.
Kontopidis G, Wu SY, Zheleva DI, Taylor P, McInnes C, Lane DP, Fischer PM, Walkinshaw MD.
Proc Natl Acad Sci U S A. 2005 Feb 8; 102(6):1871-6. Epub 2005 Jan 28.
[Proc Natl Acad Sci U S A. 2005]
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