Metal-Based Nanoparticles for the Treatment of Infectious Diseases

Molecules. 2017 Aug 18;22(8):1370. doi: 10.3390/molecules22081370.

Abstract

Infectious diseases can be transmitted and they cause a significant burden on public health globally. They are the greatest world killers and it is estimated that they are responsible for the demise of over 17 million people annually. The impact of these diseases is greater in the developing countries. People with compromised immune systems and children are the most affected. Infectious diseases may be caused by bacteria, viruses, and protozoa. The treatment of infectious diseases is hampered by simultaneous resistance to multiple drugs, indicating that there is a serious and pressing need to develop new therapeutics that can overcome drug resistance. This review will focus on the recent reports of metal-based nanoparticles that are potential therapeutics for the treatment of infectious diseases and their biological efficacy (in vitro and in vivo).

Keywords: HIV; cervical cancer; herpes; infectious diseases; influenza; malaria; metal-based therapeutics; tuberculosis.

Publication types

  • Review

MeSH terms

  • Bacteria / drug effects
  • Bacteria / pathogenicity
  • Communicable Diseases / drug therapy*
  • Communicable Diseases / microbiology
  • Communicable Diseases / parasitology
  • Communicable Diseases / virology
  • Drug Resistance, Multiple*
  • Humans
  • Metal Nanoparticles / therapeutic use*
  • Viruses / drug effects
  • Viruses / pathogenicity