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Nature. 1986 Dec 18-31;324(6098):635-40.

The c-erb-A protein is a high-affinity receptor for thyroid hormone.


Hormone binding and localization of the c-erb-A protein suggest that it is a receptor for thyroid hormone, a nuclear protein that binds to DNA and activates transcription. In contrast, the product of the viral oncogene v-erb-A is defective in binding the hormone but is still located in the nucleus.

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