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A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus (D17S1) at 17p13.
Restriction fragment length polymorphisms (RFLPs) have been developed for an adult human skeletal muscle myosin heavy chain gene which was previously mapped to the short arm of human chromosome 17. Using RFLP analysis of DNA from 140 individuals, we have found tight linkage (LOD score of 6.9) between this myosin heavy chain gene and the anonymous DNA probe, D17S1.
PMID: 2877813 [PubMed - indexed for MEDLINE]
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Cited by 9 PubMed Central articles
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Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.
Weiss A, McDonough D, Wertman B, Acakpo-Satchivi L, Montgomery K, Kucherlapati R, Leinwand L, Krauter K.
Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2958-63.
[Proc Natl Acad Sci U S A. 1999]
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Arch fingerprints, hypotonia, and areflexia associated with X linked mental retardation.
Stevenson RE, Häne B, Arena JF, May M, Lawrence L, Lubs HA, Schwartz CE.
J Med Genet. 1997 Jun; 34(6):465-9.
[J Med Genet. 1997]
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Deletion (X)(q26.1-->q28) in a proband and her mother: molecular characterization and phenotypic-karyotypic deductions.
Tharapel AT, Anderson KP, Simpson JL, Martens PR, Wilroy RS Jr, Llerena JC Jr, Schwartz CE.
Am J Hum Genet. 1993 Mar; 52(3):463-71.
[Am J Hum Genet. 1993]
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