Format

Send to:

Choose Destination
See comment in PubMed Commons below
Lancet. 1986 Aug 30;2(8505):489-91.

Intracellular surveillance of persisting viral infections. Human genital cancer results from deficient cellular control of papillomavirus gene expression.

Abstract

A model is proposed to explain basic features of viral oncogenesis in man such as the long interval between primary infection and tumour appearance, the small number of infected individuals in whom cancer develops, and the monoclonality of the tumours. These cancers are viewed as the result of failing intracellular control of persisting viral genomes in proliferating cells. This type of intracellular surveillance is regarded as a defence mechanism ancestrally older than immunological control, protecting the host at cellular level against potentially lethal effects of coevolving persisting viruses.

PMID:
2875241
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk