The medicinal chemistry of Chikungunya virus

Bioorg Med Chem. 2017 Aug 15;25(16):4219-4244. doi: 10.1016/j.bmc.2017.06.049. Epub 2017 Jun 29.

Abstract

Arthropod-borne viruses (arboviruses) are an important threat to human and animal health globally. Among these, zoonotic diseases account for billions of cases of human illness and millions of deaths every year, representing an increasing public health problem. Chikungunya virus belongs to the genus Alphavirus of the family Togariridae, and is transmitted mainly by the bite of female mosquitoes of the Aedes aegypti and/or A. albopictus species. The focus of this review will be on the medicinal chemistry of Chikungunya virus, including synthetic and natural products, as well as rationally designed compounds.

Keywords: Chikungunya; In silico; Medicinal chemistry; Natural products; Synthesis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Biological Products / chemical synthesis
  • Biological Products / chemistry
  • Biological Products / pharmacology*
  • Chemistry, Pharmaceutical
  • Chikungunya Fever / drug therapy*
  • Chikungunya virus / drug effects*
  • Dose-Response Relationship, Drug
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Structure-Activity Relationship

Substances

  • Antiviral Agents
  • Biological Products