Abstract
To test the effect of transplantation of T-cell-depleted bone marrow on recipient immune function the results of pre-transplantation immunisation with tetanus toxoid and hepatitis-B vaccine were studied in 38 donor-recipient pairs. Immunisation of the donor alone resulted in transfer of an antibody response to the recipient; immunisation of both donor and recipient resulted in potentiation of the antibody response in both magnitude and duration. These findings indicate that donor T-cell-depleted marrow can transfer humoral immunity to the recipient and that appropriate pre-transplant immunisation schedules may be of benefit to the recipient.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Adolescent
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Adult
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Anemia, Aplastic / immunology
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Anemia, Aplastic / therapy
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Antibody Formation
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Antibody-Producing Cells / immunology
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B-Lymphocytes / immunology*
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B-Lymphocytes / transplantation
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Bone Marrow / immunology
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Bone Marrow Cells
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Bone Marrow Transplantation*
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Child
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Child, Preschool
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Graft vs Host Disease / prevention & control
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Humans
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Immunization, Passive*
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Immunization, Secondary
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Immunoglobulin G / analysis
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In Vitro Techniques
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Infant
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Leukemia / immunology
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Leukemia / therapy*
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Middle Aged
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T-Lymphocytes / immunology*
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Thalassemia / immunology
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Thalassemia / therapy