Transfer of a functioning humoral immune system in transplantation of T-lymphocyte-depleted bone marrow

Lancet. 1986 Feb 15;1(8477):339-43. doi: 10.1016/s0140-6736(86)92315-9.

Abstract

To test the effect of transplantation of T-cell-depleted bone marrow on recipient immune function the results of pre-transplantation immunisation with tetanus toxoid and hepatitis-B vaccine were studied in 38 donor-recipient pairs. Immunisation of the donor alone resulted in transfer of an antibody response to the recipient; immunisation of both donor and recipient resulted in potentiation of the antibody response in both magnitude and duration. These findings indicate that donor T-cell-depleted marrow can transfer humoral immunity to the recipient and that appropriate pre-transplant immunisation schedules may be of benefit to the recipient.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Anemia, Aplastic / immunology
  • Anemia, Aplastic / therapy
  • Antibody Formation
  • Antibody-Producing Cells / immunology
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / transplantation
  • Bone Marrow / immunology
  • Bone Marrow Cells
  • Bone Marrow Transplantation*
  • Child
  • Child, Preschool
  • Graft vs Host Disease / prevention & control
  • Humans
  • Immunization, Passive*
  • Immunization, Secondary
  • Immunoglobulin G / analysis
  • In Vitro Techniques
  • Infant
  • Leukemia / immunology
  • Leukemia / therapy*
  • Middle Aged
  • T-Lymphocytes / immunology*
  • Thalassemia / immunology
  • Thalassemia / therapy

Substances

  • Immunoglobulin G