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A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormone.
The cloned complementary DNA sequence encoding the human gonadotropin-releasing hormone (GnRH) precursor protein was used to construct an expression vector for the bacterial synthesis of the 56-amino acid GnRH-associated peptide (GAP). GAP was found to be a potent inhibitor of prolactin secretion and to stimulate the release of gonadotropins in rat pituitary cell cultures. Active immunization with peptides corresponding to GAP sequences led to greatly increased prolactin secretion in rabbits.
PMID: 2863757 [PubMed - indexed for MEDLINE]
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Cited by 4 PubMed Central articles
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Micromethod for the determination of free and total prolactin receptors: measurement of receptor levels in normal and malignant mammary and prostate tissues.
Ben-David M, Kadar T, Schally AV.
Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8375-9.
[Proc Natl Acad Sci U S A. 1986]
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Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat.
Adelman JP, Mason AJ, Hayflick JS, Seeburg PH.
Proc Natl Acad Sci U S A. 1986 Jan; 83(1):179-83.
[Proc Natl Acad Sci U S A. 1986]
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Processing of thyrotropin-releasing hormone prohormone (pro-TRH) generates a biologically active peptide, prepro-TRH-(160-169), which regulates TRH-induced thyrotropin secretion.
Bulant M, Roussel JP, Astier H, Nicolas P, Vaudry H.
Proc Natl Acad Sci U S A. 1990 Jun; 87(12):4439-43.
[Proc Natl Acad Sci U S A. 1990]
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