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Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis.
10 out of 17 (59%) patients with tropical spastic paraparesis (TSP) had antibodies to human T-lymphotropic virus-I (HTLV-I), as did 5 out of 5 TSP patients with systemic symptoms. Only 13 out of 303 (4%) controls, made up of blood donors, medical personnel, and other neurological patients, had such antibodies. These findings suggest either that HTLV-I is neurotropic or that the virus or a related one contributes to the pathogenesis of TSP.
PMID: 2863442 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Saito M, Matsuzaki T, Satou Y, Yasunaga J, Saito K, Arimura K, Matsuoka M, Ohara Y.
Retrovirology. 2009 Feb 19; 6:19. Epub 2009 Feb 19.
[Retrovirology. 2009]
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MicroRNA miR-146a and further oncogenesis-related cellular microRNAs are dysregulated in HTLV-1-transformed T lymphocytes.
Pichler K, Schneider G, Grassmann R.
Retrovirology. 2008 Nov 12; 5:100. Epub 2008 Nov 12.
[Retrovirology. 2008]
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Alteration of blood-brain barrier integrity by retroviral infection.
Afonso PV, Ozden S, Cumont MC, Seilhean D, Cartier L, Rezaie P, Mason S, Lambert S, Huerre M, Gessain A, et al.
PLoS Pathog. 2008 Nov; 4(11):e1000205. Epub 2008 Nov 14.
[PLoS Pathog. 2008]
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