Structural Basis for CD4+ T Cell Epitope Dominance in Arbo-Flavivirus Envelope Proteins: A Meta-Analysis

Viral Immunol. 2017 Sep;30(7):479-489. doi: 10.1089/vim.2017.0008. Epub 2017 Jun 14.

Abstract

A meta-analysis of CD4+ T cell epitope maps reveals clusters and gaps in envelope-protein (E protein) immunogenicity that can be explained by the likelihood of epitope processing, as determined by E protein three-dimensional structures. Differential processing may be at least partially responsible for variations in disease severity among arbo-flaviruses and points to structural features that modulate protection from disease.

Keywords: antigen processing; class II MHC protein; helper T cell.

Publication types

  • Meta-Analysis

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • Databases, Protein
  • Epitope Mapping
  • Epitopes, T-Lymphocyte / chemistry*
  • Epitopes, T-Lymphocyte / metabolism
  • Flavivirus / immunology*
  • Histocompatibility Antigens Class II / metabolism
  • Humans
  • Immunodominant Epitopes / chemistry*
  • Immunodominant Epitopes / metabolism
  • Models, Immunological*
  • Protein Binding
  • Protein Conformation
  • Structure-Activity Relationship
  • Viral Envelope Proteins / chemistry*
  • Viral Envelope Proteins / immunology
  • Viral Envelope Proteins / metabolism

Substances

  • Epitopes, T-Lymphocyte
  • Histocompatibility Antigens Class II
  • Immunodominant Epitopes
  • Viral Envelope Proteins