Abstract
A meta-analysis of CD4+ T cell epitope maps reveals clusters and gaps in envelope-protein (E protein) immunogenicity that can be explained by the likelihood of epitope processing, as determined by E protein three-dimensional structures. Differential processing may be at least partially responsible for variations in disease severity among arbo-flaviruses and points to structural features that modulate protection from disease.
Keywords:
antigen processing; class II MHC protein; helper T cell.
MeSH terms
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Animals
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CD4-Positive T-Lymphocytes / immunology*
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CD4-Positive T-Lymphocytes / metabolism
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Databases, Protein
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Epitope Mapping
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Epitopes, T-Lymphocyte / chemistry*
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Epitopes, T-Lymphocyte / metabolism
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Flavivirus / immunology*
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Histocompatibility Antigens Class II / metabolism
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Humans
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Immunodominant Epitopes / chemistry*
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Immunodominant Epitopes / metabolism
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Models, Immunological*
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Protein Binding
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Protein Conformation
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Structure-Activity Relationship
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Viral Envelope Proteins / chemistry*
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Viral Envelope Proteins / immunology
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Viral Envelope Proteins / metabolism
Substances
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Epitopes, T-Lymphocyte
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Histocompatibility Antigens Class II
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Immunodominant Epitopes
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Viral Envelope Proteins