Abstract
SKF 10,047, known as an agonist of sigma opiate receptors of the brain, specifically interacts with the surface of embryonic cells of the loach inducing clustering of concanavalin A receptors, changing rheological properties of the membrane and causing the detachment of the cultivated cells from the glass. Both, in situ and in vitro, the rate of cellular aggregation increases together with the increase in the local density of aggregates; aggregation looses its spatial homogeneity. Therefore, there is a direct relationship between destabilization of spatially homogeneous condition at the cellular and supracellular levels.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Blastoderm / drug effects
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Blastoderm / ultrastructure
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Cell Aggregation / drug effects
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Concanavalin A / analogs & derivatives
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Concanavalin A / pharmacology
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Cypriniformes / embryology*
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Fluorescein-5-isothiocyanate* / analogs & derivatives*
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Fluoresceins / pharmacology
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Fluorescent Dyes / pharmacology
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Microscopy, Electron, Scanning
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Morphogenesis / drug effects
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Phenazocine / analogs & derivatives*
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Phenazocine / pharmacology
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Receptors, Concanavalin A / drug effects
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Receptors, Opioid / drug effects*
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Receptors, sigma
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Surface Properties
Substances
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Fluoresceins
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Fluorescent Dyes
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Receptors, Concanavalin A
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Receptors, Opioid
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Receptors, sigma
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fluorescein isothiocyanate-concanavalin A
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Concanavalin A
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SK&F 10047
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Fluorescein-5-isothiocyanate
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Phenazocine