FEBS Lett. 1988 Dec 5;241(1-2):83-8.

The Saccharomyces cerevisiae ARO1 gene. An example of the co-ordinate regulation of five enzymes on a single biosynthetic pathway.

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Department of Biochemistry, University of Glasgow, Scotland.

Abstract

The ARO1 gene of Saccharomyces cerevisiae encodes the arom multifunctional enzyme. Specific inhibitors of amino acid biosynthesis have been used to obtain evidence that expression of a cloned ARO1 gene is regulated in response to amino acid limitation. Northern blot analysis and sequence studies indicate that ARO1 is regulated by the well characterised S. cerevisiae 'general control' mechanism. This provides a very economical means of simultaneously tailoring the synthesis of five shikimate pathway enzymes to the needs of the cell.

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The pentafunctional arom enzyme of Saccharomyces cerevisiae is a mosaic of monofunctional domains. [Biochem J. 1987]
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