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J Natl Cancer Inst. 1988 Dec 21;80(20):1626-8.

Hepatoblastoma and familial adenomatous polyposis.

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  • 1Dana-Farber Cancer Institute, Boston, MA 02115.

Erratum in

  • J Natl Cancer Inst 1989 Mar 15;81(6):461.

Abstract

Eleven children have been identified as having hepatoblastoma and a family history of adenomatous polyposis, and 14 additional instances of this association have been collected from the literature. Among the 11 survivors of hepatoblastoma in the combined series, adenomatous lesions have been sought in seven and detected in six patients at ages 7 to 25 years. Five of these patients also have congenital hypertrophy of the retinal pigment epithelium, a marker for carriers of the polyposis gene. These findings strengthen the association between hepatoblastoma and familial adenomatous polyposis and have led to the establishment of the Hepatoblastoma-Adenomatous Polyposis Registry.

PMID:
2848134
[PubMed - indexed for MEDLINE]
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