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Plasminogen activator inhibitor 2. Isolation and characterization of the promoter region of the gene.
Department of Medicine, University Hospital, Lausanne, Switzerland.
We have isolated the promoter region and part of the coding region of the human plasminogen activator inhibitor 2 gene. The first two exons (65 and 177 base pairs, respectively) are separated by a 3.6 kilo base pair intron. More than 2 kilo base pair of the promoter region was sequenced and analyzed. The promoter region is characterized by: a) a TATAAA box located 31 base pairs upstream of the transcription initiation site; b) a 123 base pair stretch (-598 to -720) that is homologous (greater than 90% identity) to the inverted sequence of -1268 to -1380; c) a 24 base pair inverted repeat at -276 to -299 and three direct repeats; and d) several sequences that are homologous (up to 1 mismatch) to the cAMP responsive element or to binding sites for the transcription factors AP1 and AP2.
PMID: 2845977 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1.
Benanti JA, Williams DK, Robinson KL, Ozer HL, Galloway DA.
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[Mol Cell Biol. 2002]
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BOX DNA: a novel regulatory element related to embryonal carcinoma cell differentiation.
Kihara-Negishi F, Tsujita R, Negishi Y, Ariga H.
Mol Cell Biol. 1993 Dec; 13(12):7747-56.
[Mol Cell Biol. 1993]
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Regulatory elements involved in constitutive and phorbol ester-inducible expression of the plasminogen activator inhibitor type 2 gene promoter.
Cousin E, Medcalf RL, Bergonzelli GE, Kruithof EK.
Nucleic Acids Res. 1991 Jul 25; 19(14):3881-6.
[Nucleic Acids Res. 1991]