Abstract
Tissue distribution of synthetic neoglycoproteins was studied after intravenous injection of 125I-labeled galactosyl-, mannosyl- and fucosyl-BSA. The highest uptake of all three reagents occurred in the bone marrow. Spleen also took up considerable proportions of galactosyl and mannosyl reagents, while liver only took up galactosyl-BSA. Implication of these findings in the recognition and homing of intravenously transplanted hemopoietic cells to bone marrow is discussed.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Bone Marrow / metabolism*
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Bone Marrow Cells
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Galactose / pharmacokinetics*
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Hematopoietic Stem Cells / metabolism*
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Indicators and Reagents
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Infusions, Intravenous
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Mice
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Mice, Inbred C57BL
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Receptors, Cell Surface / metabolism
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Serum Albumin, Bovine / pharmacokinetics*
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Tissue Distribution
Substances
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Indicators and Reagents
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Receptors, Cell Surface
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bovine serum albumin-galactose (39)
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galactose receptor
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Serum Albumin, Bovine
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Galactose