Marrow uptake of galactosyl-containing neoglycoproteins: implications in stem cell homing

Exp Hematol. 1988 Oct;16(9):811-3.

Abstract

Tissue distribution of synthetic neoglycoproteins was studied after intravenous injection of 125I-labeled galactosyl-, mannosyl- and fucosyl-BSA. The highest uptake of all three reagents occurred in the bone marrow. Spleen also took up considerable proportions of galactosyl and mannosyl reagents, while liver only took up galactosyl-BSA. Implication of these findings in the recognition and homing of intravenously transplanted hemopoietic cells to bone marrow is discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bone Marrow / metabolism*
  • Bone Marrow Cells
  • Galactose / pharmacokinetics*
  • Hematopoietic Stem Cells / metabolism*
  • Indicators and Reagents
  • Infusions, Intravenous
  • Mice
  • Mice, Inbred C57BL
  • Receptors, Cell Surface / metabolism
  • Serum Albumin, Bovine / pharmacokinetics*
  • Tissue Distribution

Substances

  • Indicators and Reagents
  • Receptors, Cell Surface
  • bovine serum albumin-galactose (39)
  • galactose receptor
  • Serum Albumin, Bovine
  • Galactose