New phenolic acids from Salvia yunnanensis C.H.Wright

Nat Prod Res. 2017 Nov;31(21):2505-2512. doi: 10.1080/14786419.2017.1315577. Epub 2017 Apr 18.

Abstract

Two new phenolic acids, ethyl pro-lithospermate (1), n-butyl pro-lithospermate (2) were isolated from Salvia yunnanensis C.H.Wright, along with nineteen known compounds (3-21). The structures of the isolated compounds were elucidated on the basis of extensive spectrometry and by comparing their physical and spectroscopic data to the literature. Among them, compounds 11, 12 and 14-16 were firstly isolated from S. yunnanensis C.H.Wright. Some of the isolated compounds were evaluated for their neuroprotection. Compounds 10-12 showed significant neuroprotective effects in PC12 cells and compounds 1, 4-7 displayed moderate neuroprotective effects.

Keywords: Salvia yunnanensis; neuroprotection; phenolic acids; phenylpropanoids.

MeSH terms

  • Animals
  • Drug Evaluation, Preclinical / methods
  • Hydrogen Peroxide / toxicity
  • Hydroxybenzoates / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Neuroprotective Agents / chemistry*
  • Neuroprotective Agents / pharmacology*
  • PC12 Cells
  • Plant Extracts / chemistry
  • Rats
  • Salvia / chemistry*
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Hydroxybenzoates
  • Neuroprotective Agents
  • Plant Extracts
  • Hydrogen Peroxide
  • phenolic acid