J Bacteriol. 1988 Aug;170(8):3725-30.

Salmonella typhimurium mutants lacking NAD pyrophosphatase.

Source

Department of Biology, University of Utah, Salt Lake City 84112.

Abstract

NAD can serve as both a purine and a pyridine source for Salmonella typhimurium. Exogenous NAD is rapidly broken down into nicotinamide mononucleotide and AMP by an NAD pyrophosphatase, the first step in the pathway for the assimilation of exogenous NAD. We isolated and characterized mutants of S. typhimurium lacking NAD pyrophosphatase activity; such mutants were identified by their failure to use exogenous NAD as a purine source. These mutants carry mutations that map at a new locus, designated pnuE, between 86 and 87 min on the Salmonella chromosome.

PMID:: 2841298; [PubMed - indexed for MEDLINE]
PMCID:: PMC211351

Free PMC Article

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Pyridine nucleotide cycle of Salmonella typhimurium: isolation and characterization of pncA, pncB, and pncC mutants and utilization of exogenous nicotinamide adenine dinucleotide. [J Bacteriol. 1979]
Pyridine nucleotide cycle of Salmonella typhimurium: isolation and characterization of pncA, pncB, and pncC mutants and utilization of exogenous nicotinamide adenine dinucleotide.
Foster JW, Kinney DM, Moat AG. J Bacteriol. 1979 Mar; 137(3):1165-75.
Isolation of NAD cycle mutants defective in nicotinamide mononucleotide deamidase in Salmonella typhimurium. [J Bacteriol. 1995]
Isolation of NAD cycle mutants defective in nicotinamide mononucleotide deamidase in Salmonella typhimurium.
Cheng W, Roth J. J Bacteriol. 1995 Dec; 177(23):6711-7.
Mapping and characterization of the nad genes in Salmonella typhimurium LT-2. [J Bacteriol. 1978]
Mapping and characterization of the nad genes in Salmonella typhimurium LT-2.
Foster JW, Moat AG. J Bacteriol. 1978 Feb; 133(2):775-9.
NAD metabolism in Salmonella typhimurium: isolation of pyridine analogue supersensitive (pas) and pas suppressor mutants. [J Gen Microbiol. 1984]
NAD metabolism in Salmonella typhimurium: isolation of pyridine analogue supersensitive (pas) and pas suppressor mutants.
Foster JW, Holley EA, Mya S. J Gen Microbiol. 1984 Nov; 130(11):2873-81.
Review Linkage map of Salmonella typhimurium, edition VII. [Microbiol Rev. 1988]
Review Linkage map of Salmonella typhimurium, edition VII.
Sanderson KE, Roth JR. Microbiol Rev. 1988 Dec; 52(4):485-532.

See reviews... See all...

Cited by 6 PubMed Central articles

Assimilation of nicotinamide mononucleotide requires periplasmic AphA phosphatase in Salmonella enterica. [J Bacteriol. 2005]
Assimilation of nicotinamide mononucleotide requires periplasmic AphA phosphatase in Salmonella enterica.
Grose JH, Bergthorsson U, Xu Y, Sterneckert J, Khodaverdian B, Roth JR. J Bacteriol. 2005 Jul; 187(13):4521-30.
The stm4066 gene product of Salmonella enterica serovar Typhimurium has aminoimidazole riboside (AIRs) kinase activity and allows AIRs to satisfy the thiamine requirement of pur mutant strains. [J Bacteriol. 2003]
The stm4066 gene product of Salmonella enterica serovar Typhimurium has aminoimidazole riboside (AIRs) kinase activity and allows AIRs to satisfy the thiamine requirement of pur mutant strains.
Dougherty M, Downs DM. J Bacteriol. 2003 Jan; 185(1):332-9.
NadN and e (P4) are essential for utilization of NAD and nicotinamide mononucleotide but not nicotinamide riboside in Haemophilus influenzae. [J Bacteriol. 2001]
NadN and e (P4) are essential for utilization of NAD and nicotinamide mononucleotide but not nicotinamide riboside in Haemophilus influenzae.
Kemmer G, Reilly TJ, Schmidt-Brauns J, Zlotnik GW, Green BA, Fiske MJ, Herbert M, Kraiss A, Schlör S, Smith A, et al. J Bacteriol. 2001 Jul; 183(13):3974-81.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioSystems
Pathways and biological systems (BioSystems) that cite the current articles. Citations are from the BioSystems source databases (KEGG and BioCyc).
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Salmonella typhimurium mutants lacking NAD pyrophosphatase.
Salmonella typhimurium mutants lacking NAD pyrophosphatase.
J Bacteriol. 1988 Aug ;170(8):3725-30.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: