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Xenobiotica. 1988 Apr;18(4):417-27.

In vivo metabolism of the n-butyl-homologues of delta 9-tetrahydrocannabinol and delta 8-tetrahydrocannabinol by the mouse.

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  • 1University Department of Pharmacology, Oxford, UK.

Abstract

1. n-Butyl-homologues of delta 8-tetrahydrocannabinol (delta 8-THC) and delta 9-THC were synthesized from 5-butyl-1,3-dihydroxybenzene and (1S)-cis-verbenol, and the delta 9-isomer was shown to have the same g.l.c.-mass spectral characteristics as the natural product. 2. Metabolism of these cannabinoids was studied in mice following i.p. injection. Metabolites were extracted from the livers, separated from endogenous lipids by chromatography on Sephadex LH-20 and examined by g.l.c.-mass spectrometry. 3. Thirteen metabolites were identified from both n-butyl-delta 8-THC and n-butyl-delta 9-THC. 4. Major metabolic routes were hydroxylations in the 2', 3', 8 and 11 positions and oxidation of the resulting 11-hydroxy-metabolites to carboxylic acids. 5. Metabolism was very similar to that of the pentyl homologues, the major constituents of cannabis, but with the production of a greater proportion of acidic metabolites at the expense of alcohols.

PMID:
2840781
[PubMed - indexed for MEDLINE]
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