Nature. 1988 Jul 28;334(6180):320-5.

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA.

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Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

Abstract

Poliovirus RNA is naturally uncapped, therefore its translation must proceed via a cap-independent mechanism. Translation initiation on poliovirus RNA occurs by binding of ribosomes to an internal sequence within the 5' noncoding region. This novel mechanism of initiation may explain the disparate translation of several other eukaryotic messenger RNAs.

PMID:: 2839775; [PubMed - indexed for MEDLINE]

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A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein. [Proc Natl Acad Sci U S A. 1993]
A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein.
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Cited by over 100 PubMed Central articles

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Nature. 1988 Jul 28 ;334(6180):320-5.

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