Virology. 1988 Jul;165(1):209-15.

Neutralization of diverse HIV-1 strains by monoclonal antibodies raised against a gp41 synthetic peptide.

Dalgleish AG, Chanh TC, Kennedy RC, Kanda P, Clapham PR, Weiss RA.

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MRC Clinical Research Centre, Harrow, United Kingdom.

Abstract

Three IgM monoclonal antibodies raised against synthetic peptide analogs of a hydrophilic region of the gp41 transmembrane env protein of HIV-1 neutralize different HIV-1 isolates but not HIV-2 isolates, as determined by HIV titration and by syncytial inhibition assays. VSV (HIV-1) pseudotypes, however, were not neutralized, indicating that gp41 was not accessible to these antibodies on the pseudotype particles. The antibodies affect early steps in adsorption and penetration of HIV-1.

PMID:: 2838959; [PubMed - indexed for MEDLINE]

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Neutralization of diverse HIV-1 strains by monoclonal antibodies raised against a gp41 synthetic peptide.

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