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Family of human Na+, K+-ATPase genes. Structure of the gene for the catalytic subunit (alpha III-form) and its relationship with structural features of the protein.
Ovchinnikov YuA,
Monastyrskaya GS,
Broude NE,
Ushkaryov YuA,
Melkov AM,
Smirnov YuV,
Malyshev IV,
Allikmets RL,
Kostina MB,
Dulubova IE, et al.
Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, Moscow.
The primary structure of a gene of the Na+, K+-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical alpha III-form of the enzyme catalytic subunit. The gene comprises over 25,000 bp, and its protein coding region includes 23 exons and 22 introns. Possible correlation between structural features of the protein and location of introns in the gene are discussed.
PMID: 2838329 [PubMed - indexed for MEDLINE]
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Cited by 7 PubMed Central articles
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Apical plasma membrane mispolarization of NaK-ATPase in polycystic kidney disease epithelia is associated with aberrant expression of the beta2 isoform.
Wilson PD, Devuyst O, Li X, Gatti L, Falkenstein D, Robinson S, Fambrough D, Burrow CR.
Am J Pathol. 2000 Jan; 156(1):253-68.
[Am J Pathol. 2000]
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Polymorphism and structure of the gene coding for the alpha 1 subunit of the Artemia franciscana Na/K-ATPase.
García-Sáez A, Perona R, Sastre L.
Biochem J. 1997 Jan 15; 321 ( Pt 2):509-18.
[Biochem J. 1997]
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The presence of both negative and positive elements in the 5'-flanking sequence of the rat Na,K-ATPase alpha 3 subunit gene are required for brain expression in transgenic mice.
Pathak BG, Neumann JC, Croyle ML, Lingrel JB.
Nucleic Acids Res. 1994 Nov 11; 22(22):4748-55.
[Nucleic Acids Res. 1994]
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Patient Drug Information
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Potassium (Glu-K® , K+ 10® , K+ 8® , ...)
Potassium is essential for the proper functioning of the heart, kidneys, muscles, nerves, and digestive system. Usually the food you eat supplies all of the potassium you need. However, certain diseases (e.g., kidney dis...