Virology. 1988 Jun;164(2):487-97.

Measles virus L protein evidences elements of ancestral RNA polymerase.

Blumberg BM, Crowley JC, Silverman JI, Menonna J, Cook SD, Dowling PC.

Source

Neurology Service, East Orange VA Medical Center, New Jersey 07019.

Abstract

We have determined the nucleotide sequence of the measles virus (MV) L gene using a cDNA library encompassing the entire MV genome (J. Crowley et al. (1987) Intervirology, 28, 65-77). The L gene is 6639 nucleotides in length, and contains a single long open reading frame that could code for a protein of 247,611 kDa. Both the L gene and in particular the predicted L protein of MV bear substantial homology to their counterparts in Sendai virus and Newcastle disease virus, suggesting that the multifunctional nature of paramyxovirus L proteins imposes strong evolutionary constraints. The predicted MV L protein also contains distinct elements of a postulated ancestral RNA polymerase.

PMID:: 2835864; [PubMed - indexed for MEDLINE]

Supplemental Content

Save items

Related citations in PubMed

Sequence analysis of the polymerase L gene of human respiratory syncytial virus and predicted phylogeny of nonsegmented negative-strand viruses. [Virology. 1991]
Sequence analysis of the polymerase L gene of human respiratory syncytial virus and predicted phylogeny of nonsegmented negative-strand viruses.
Stec DS, Hill MG 3rd, Collins PL. Virology. 1991 Jul; 183(1):273-87.
Molecular cloning and sequence analysis of the mumps virus gene encoding the L protein and the trailer sequence. [Virology. 1992]
Molecular cloning and sequence analysis of the mumps virus gene encoding the L protein and the trailer sequence.
Okazaki K, Tanabayashi K, Takeuchi K, Hishiyama M, Okazaki K, Yamada A. Virology. 1992 Jun; 188(2):926-30.
Completion of the rabies virus genome sequence determination: highly conserved domains among the L (polymerase) proteins of unsegmented negative-strand RNA viruses. [Virology. 1988]
Completion of the rabies virus genome sequence determination: highly conserved domains among the L (polymerase) proteins of unsegmented negative-strand RNA viruses.
Tordo N, Poch O, Ermine A, Keith G, Rougeon F. Virology. 1988 Aug; 165(2):565-76.
Review Evolution of viral DNA-dependent RNA polymerases. [Virus Genes. 1995]
Review Evolution of viral DNA-dependent RNA polymerases.
Sonntag KC, Darai G. Virus Genes. 1995; 11(2-3):271-84.
Review [Genetic divergence of measles virus and clinical significance]. [Uirusu. 1997]
Review [Genetic divergence of measles virus and clinical significance].
Nakayama T, Yamaguchi S, Mori T. Uirusu. 1997 Jun; 47(1):5-13.

See reviews... See all...

Cited by 10 PubMed Central articles

Whole genomes of Chandipura virus isolates and comparative analysis with other rhabdoviruses. [PLoS One. 2012]
Whole genomes of Chandipura virus isolates and comparative analysis with other rhabdoviruses.
Cherian SS, Gunjikar RS, Banerjee A, Kumar S, Arankalle VA. PLoS One. 2012; 7(1):e30315. Epub 2012 Jan 17.
Mutations affecting transcriptional termination in the p gene end of subacute sclerosing panencephalitis viruses. [J Virol. 2002]
Mutations affecting transcriptional termination in the p gene end of subacute sclerosing panencephalitis viruses.
Ayata M, Komase K, Shingai M, Matsunaga I, Katayama Y, Ogura H. J Virol. 2002 Dec; 76(24):13062-8.
Activity of polymerase proteins of vaccine and wild-type measles virus strains in a minigenome replication assay. [J Virol. 2002]
Activity of polymerase proteins of vaccine and wild-type measles virus strains in a minigenome replication assay.
Bankamp B, Kearney SP, Liu X, Bellini WJ, Rota PA. J Virol. 2002 Jul; 76(14):7073-81.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Measles virus L protein evidences elements of ancestral RNA polymerase.
Measles virus L protein evidences elements of ancestral RNA polymerase.
Virology. 1988 Jun ;164(2):487-97.

PubMed
Transgenic mice express the human phenylethanolamine N-methyltransferase gene in...
Transgenic mice express the human phenylethanolamine N-methyltransferase gene in adrenal medulla and retina.
Proc Natl Acad Sci U S A. 1988 May ;85(10):3648-52.

PubMed
Severe and transient pancytopenia associated with a chronic arenavirus infection...
Severe and transient pancytopenia associated with a chronic arenavirus infection.
J Exp Pathol. 1987 ;3(3):259-69.

PubMed
Spectral characterization of manganese peroxidase, an extracellular heme enzyme ...
Spectral characterization of manganese peroxidase, an extracellular heme enzyme from the lignin-degrading basidiomycete, Phanerochaete chrysosporium.
J Biol Chem. 1988 May 25 ;263(15):7029-36.

PubMed
Rat neuropeptide Y precursor gene expression. mRNA structure, tissue distributio...
Rat neuropeptide Y precursor gene expression. mRNA structure, tissue distribution, and regulation by glucocorticoids, cyclic AMP, and phorbol ester.
J Biol Chem. 1988 May 5 ;263(13):6288-95.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Measles virus L protein evidences elements of ancestral RNA polymerase.

Source

Abstract

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types

MeSH Terms

Substances

Secondary Source ID

Supplemental Content

Save items

Related citations in PubMed

Cited by 10 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information