Abstract
Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is composed of an O2-regulated HIF-1α subunit and a constitutively expressed HIF-1β subunit. This review provides a compendium of proteins that interact with the HIF-1α subunit, many of which regulate HIF-1 activity in either an O2-dependent or O2-independent manner.
Keywords:
Oxygen biology; Transcriptional regulation.
Copyright © 2017 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, N.I.H., Extramural
MeSH terms
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Aryl Hydrocarbon Receptor Nuclear Translocator / metabolism*
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Cell Hypoxia / physiology
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Humans
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Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
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Nuclear Proteins / metabolism*
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Oxygen / metabolism*
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Transcription Factors / metabolism*
Substances
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ARNT protein, human
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Hypoxia-Inducible Factor 1, alpha Subunit
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Nuclear Proteins
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Transcription Factors
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Aryl Hydrocarbon Receptor Nuclear Translocator
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Oxygen