A compendium of proteins that interact with HIF-1α

Exp Cell Res. 2017 Jul 15;356(2):128-135. doi: 10.1016/j.yexcr.2017.03.041. Epub 2017 Mar 20.

Abstract

Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is composed of an O2-regulated HIF-1α subunit and a constitutively expressed HIF-1β subunit. This review provides a compendium of proteins that interact with the HIF-1α subunit, many of which regulate HIF-1 activity in either an O2-dependent or O2-independent manner.

Keywords: Oxygen biology; Transcriptional regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aryl Hydrocarbon Receptor Nuclear Translocator / metabolism*
  • Cell Hypoxia / physiology
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
  • Nuclear Proteins / metabolism*
  • Oxygen / metabolism*
  • Transcription Factors / metabolism*

Substances

  • ARNT protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Nuclear Proteins
  • Transcription Factors
  • Aryl Hydrocarbon Receptor Nuclear Translocator
  • Oxygen