Blood. 1979 Feb;53(2):264-8.

Chronic myelocytic leukemia (CML): failure to detect residual normal committed stem cells in vitro.

Singer JW, Fialkow PJ, Steinmann L, Najfeld V, Stein SJ, Robinson WA.

Abstract

Granulocytic colonies grown in culture from marrow and peripheral blood from five patients with Ph1-positive CML and heterozygous at the G-6-PD locus were analyzed for G-6-PD in order to identify CFU-C that do not arise from the CML clone. The patients had both B and A enzymes in normal tissues, but their CML clones typed as B. Whereas about 50% of colonies from normal subjects heterozygous as the G-6-PD locus show type-A G-6-PD and 50% type B, only two of the 1308 colonies from the CML patients had type-A G-6-PD. These data provide little evidence for persistence of normal committed stem cells in CML, a finding in contrast to that made previously in polycythemia vera, another clonal stem cell myeloproliferative disorder.

PMID:: 282920; [PubMed - indexed for MEDLINE]

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