Lipids. 1987 Oct;22(10):711-4.

Enteral absorption in man of eicosapentaenoic acid in different chemical forms.

el Boustani S, Colette C, Monnier L, Descomps B, Crastes de Paulet A, Mendy F.

Source

Laboratoire de Biochimie A, Institut de Biologie, Montpellier, France.

Abstract

After administering the equivalent of 1 g of eicosapentaenoic acid (EPA) in four different chemical forms, the kinetics of EPA incorporation into plasma triglycerides (TG) were compared by gas liquid chromatography on a capillary column following separation of the lipid fraction by thin layer chromatography. EPA incorporation into plasma TG was markedly smaller and later when EPA was administered as an ethyl ester rather than as EPA free fatty acid, EPA arginine salt or 1,3-dioctanoyl-2-eicosapentaenoyl glycerol (2-EPA). Our results and the data in the literature are compatible with the hypothesis that 2-EPA is absorbed with minimum hydrolysis and escapes random distribution between the other positions of the glycerol molecule during the absorption process.

PMID:: 2828810; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Dietary Fats - MedlinePlus Health Information

Molecular Biology Databases

(L)-ARGININE - HSDB

Supplemental Content

Save items

Related citations in PubMed

The enteral bioavailability of eicosapentaenoic acid and docosahexaenoic acid is as good from ethyl esters as from glyceryl esters in spite of lower hydrolytic rates by pancreatic lipase in vitro. [Biochim Biophys Acta. 1993]
The enteral bioavailability of eicosapentaenoic acid and docosahexaenoic acid is as good from ethyl esters as from glyceryl esters in spite of lower hydrolytic rates by pancreatic lipase in vitro.
Krokan HE, Bjerve KS, Mørk E. Biochim Biophys Acta. 1993 May 20; 1168(1):59-67.
[Comparative bioavailability of eicosapentaenoic acid and docasahexaenoic acid from triglycerides, free fatty acids and ethyl esters in volunteers]. [Arzneimittelforschung. 1990]
[Comparative bioavailability of eicosapentaenoic acid and docasahexaenoic acid from triglycerides, free fatty acids and ethyl esters in volunteers].
Beckermann B, Beneke M, Seitz I. Arzneimittelforschung. 1990 Jun; 40(6):700-4.
Digestion and lymphatic transport of eicosapentaenoic and docosahexaenoic acids given in the form of triacylglycerol, free acid and ethyl ester in rats. [Biochim Biophys Acta. 1995]
Digestion and lymphatic transport of eicosapentaenoic and docosahexaenoic acids given in the form of triacylglycerol, free acid and ethyl ester in rats.
Ikeda I, Sasaki E, Yasunami H, Nomiyama S, Nakayama M, Sugano M, Imaizumi K, Yazawa K. Biochim Biophys Acta. 1995 Dec 7; 1259(3):297-304.
Review Microdetermination of fatty acids by gas chromatography and cardiovascular risk stratification by the "EPA+DHA level". [Herz. 2006]
Review Microdetermination of fatty acids by gas chromatography and cardiovascular risk stratification by the "EPA+DHA level".
Rupp H, Rupp TP, Wagner D, Alter P, Maisch B. Herz. 2006 Dec; 31 Suppl 3:30-49.
Review Risk stratification by the "EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and antiarrhythmogenic effects of long-chain omega-3 fatty acids. [Herz. 2004]
Review Risk stratification by the "EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and antiarrhythmogenic effects of long-chain omega-3 fatty acids.
Rupp H, Wagner D, Rupp T, Schulte LM, Maisch B. Herz. 2004 Nov; 29(7):673-85.

See reviews... See all...

Cited by 3 PubMed Central articles

Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations--a comparative bioavailability study of fish oil vs. krill oil. [Lipids Health Dis. 2011]
Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations--a comparative bioavailability study of fish oil vs. krill oil.
Schuchardt JP, Schneider I, Meyer H, Neubronner J, von Schacky C, Hahn A. Lipids Health Dis. 2011 Aug 22; 10:145. Epub 2011 Aug 22.
Developing intestine is injured during absorption of oleic acid but not its ethyl ester. [J Clin Invest. 1994]
Developing intestine is injured during absorption of oleic acid but not its ethyl ester.
Velasquez OR, Place AR, Tso P, Crissinger KD. J Clin Invest. 1994 Feb; 93(2):479-85.
High dose eicosapentaenoic acid ethyl ester: effects on lipids and neutrophil leukotriene production in normal volunteers. [Br J Clin Pharmacol. 1990]
High dose eicosapentaenoic acid ethyl ester: effects on lipids and neutrophil leukotriene production in normal volunteers.
Hawthorne AB, Filipowicz BL, Edwards TJ, Hawkey CJ. Br J Clin Pharmacol. 1990 Aug; 30(2):187-94.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Enteral absorption in man of eicosapentaenoic acid in different chemical forms.
Enteral absorption in man of eicosapentaenoic acid in different chemical forms.
Lipids. 1987 Oct ;22(10):711-4.

PubMed
Viral etiology of testicular tumors.
Viral etiology of testicular tumors.
J Urol. 1988 Feb ;139(2):308-10.

PubMed
Cellular basis of defective sperm function and its association with the genesis ...
Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa.
J Reprod Fertil. 1987 Nov ;81(2):459-69.

PubMed
Toward a rational pharmacotherapy for aggressive and violent behavior.
Toward a rational pharmacotherapy for aggressive and violent behavior.
Hosp Community Psychiatry. 1988 Jan ;39(1):31-9.

PubMed
Ventilatory physiology of patients with panic disorder.
Ventilatory physiology of patients with panic disorder.
Arch Gen Psychiatry. 1988 Jan ;45(1):31-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: