A new route for the synthesis of [18F]fluoroaromatic substituted amino acids: no carrier added L-p-[18F]fluorophenylalanine

Int J Rad Appl Instrum A. 1987;38(12):1033-8. doi: 10.1016/0883-2889(87)90066-9.

Abstract

L-p-[18F]fluorophenylalanine was designed as a potential marker for probing protein synthesis in the human brain by positron emission tomography. This radiotracer has been synthesized using nucleophilic displacement of the activated nitro group of p-nitrobenzaldehyde by NCA 18F- obtained from the 18O (p, n) reaction on enriched water. The L-form of the [18F]fluoroamino acid can be separated on an analytical scale chiral column. A typical production run of 22.2 GBq (600 mCi) of 18F obtained after a 10 microA.h bombardment of 18 MeV protons on 99.8% 18O-enriched water leads to a batch of 1.11 GBq (30 mCi) of NCA L-p-[18F]fluorophenylalanine after a total synthesis time of 120 min.

MeSH terms

  • Chromatography, High Pressure Liquid
  • Fluorine Radioisotopes*
  • Indicators and Reagents
  • Isotope Labeling / methods
  • Phenylalanine / analogs & derivatives*
  • p-Fluorophenylalanine / chemical synthesis*

Substances

  • Fluorine Radioisotopes
  • Indicators and Reagents
  • Phenylalanine
  • p-Fluorophenylalanine