Trained Immunity: An Ancient Way of Remembering

Mihai G Netea; Jos W M van der Meer

doi:10.1016/j.chom.2017.02.003

Trained Immunity: An Ancient Way of Remembering

Cell Host Microbe. 2017 Mar 8;21(3):297-300. doi: 10.1016/j.chom.2017.02.003.

Authors

Mihai G Netea¹, Jos W M van der Meer²

Affiliations

¹ Department of Internal Medicine, Radboud University Medical Centre, PO box 9101, 6500HB Nijmegen, the Netherlands. Electronic address: mihai.netea@radboudumc.nl.
² Department of Internal Medicine, Radboud University Medical Centre, PO box 9101, 6500HB Nijmegen, the Netherlands. Electronic address: jos.vandermeer@radboudumc.nl.

PMID: 28279335
DOI: 10.1016/j.chom.2017.02.003

Abstract

The innate arm of the immune system has generally been regarded as primitive and non-specific and, in contrast to adaptive immunity, not to possess memory. Here we review the growing body of evidence that innate immunity has an important capacity to adapt, a de facto innate immune memory (also termed trained immunity), and this provides broad protection against infections.

Keywords: cytokines; infections; innate immune memory; trained immunity; vertebrate immunity.

Publication types

Review

MeSH terms

Animals
Humans
Immunity, Innate*
Immunologic Memory*