Low serum HDL-cholesterol concentrations in mid-life predict late-life cognitive impairment in type 2 diabetes: The Fremantle diabetes study

David G Bruce; Wendy A Davis; Timothy M E Davis

doi:10.1016/j.jdiacomp.2016.12.009

Low serum HDL-cholesterol concentrations in mid-life predict late-life cognitive impairment in type 2 diabetes: The Fremantle diabetes study

J Diabetes Complications. 2017 Jun;31(6):945-947. doi: 10.1016/j.jdiacomp.2016.12.009. Epub 2017 Jan 20.

Authors

David G Bruce¹, Wendy A Davis², Timothy M E Davis²

Affiliations

¹ School of Medicine & Pharmacology, University of Western Australia. Electronic address: david.bruce@uwa.edu.au.
² School of Medicine & Pharmacology, University of Western Australia.

PMID: 28258907
DOI: 10.1016/j.jdiacomp.2016.12.009

Abstract

In a study involving patients with type 2 diabetes assessed annually over 5years, serum HDL-cholesterol was the sole mid-life metabolic predictor of late-life cognitive impairment.

Keywords: Cognitive impairment; HDL cholesterol; Longitudinal study; Type 2 diabetes.

Publication types

Observational Study

MeSH terms

Age Factors
Age of Onset
Aged
Aged, 80 and over
Cholesterol, HDL / blood*
Cognitive Dysfunction / blood
Cognitive Dysfunction / complications
Cognitive Dysfunction / diagnosis*
Cognitive Dysfunction / epidemiology*
Diabetes Mellitus, Type 2 / complications
Diabetes Mellitus, Type 2 / diagnosis
Diabetes Mellitus, Type 2 / epidemiology*
Diabetes Mellitus, Type 2 / psychology*
Female
Humans
Hypoalphalipoproteinemias / blood
Hypoalphalipoproteinemias / complications
Hypoalphalipoproteinemias / epidemiology*
Hypoalphalipoproteinemias / psychology
Longitudinal Studies
Male
Middle Aged
Prognosis
Risk Factors

Substances

Cholesterol, HDL