Proc Natl Acad Sci U S A. 1987 Nov;84(22):8120-4.

Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.

Walker BD, Kowalski M, Goh WC, Kozarsky K, Krieger M, Rosen C, Rohrschneider L, Haseltine WA, Sodroski J.

Source

Infectious Disease Unit, Massachusetts General Hospital, Boston.

Abstract

Castanospermine (1,6,7,8-tetrahydroxyoctahydroindolizine) is a plant alkaloid that modifies glycosylation by inhibiting alpha-glucosidase I. Castanospermine is shown to inhibit syncytium formation induced by the envelope glycoprotein of the human immunodeficiency virus and to inhibit viral replication. The decrease in syncytium formation in the presence of castanospermine can be attributed to inhibition of processing of the envelope precursor protein gp160, with resultant decreased cell surface expression of the mature envelope glycoprotein gp120. In addition, castanospermine may cause defects in steps involved in membrane fusion after binding of CD4 antigen. The antiviral effects of castanospermine may be due to modifications of the envelope glycoprotein that affect the ability of the virus to enter cells after attachment to the CD4 cell receptor.

PMID:: 2825177; [PubMed - indexed for MEDLINE]
PMCID:: PMC299490

Free PMC Article

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Supplemental Content

Save items

Related citations in PubMed

A soluble CD4 protein selectively inhibits HIV replication and syncytium formation. [Nature. 1988]
A soluble CD4 protein selectively inhibits HIV replication and syncytium formation.
Hussey RE, Richardson NE, Kowalski M, Brown NR, Chang HC, Siliciano RF, Dorfman T, Walker B, Sodroski J, Reinherz EL. Nature. 1988 Jan 7; 331(6151):78-81.
HIV infection is blocked in vitro by recombinant soluble CD4. [Nature. 1988]
HIV infection is blocked in vitro by recombinant soluble CD4.
Fisher RA, Bertonis JM, Meier W, Johnson VA, Costopoulos DS, Liu T, Tizard R, Walker BD, Hirsch MS, Schooley RT. Nature. 1988 Jan 7; 331(6151):76-8.
Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. [Nature. 1987]
Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.
Gruters RA, Neefjes JJ, Tersmette M, de Goede RE, Tulp A, Huisman HG, Miedema F, Ploegh HL. Nature. 1987 Nov 5-11; 330(6143):74-7.
Review Characterization of CD4 glycoprotein determinant-HIV envelope protein interactions: perspectives for analog and vaccine development. [Crit Rev Immunol. 1988]
Review Characterization of CD4 glycoprotein determinant-HIV envelope protein interactions: perspectives for analog and vaccine development.
Farrar WL, Harel-Bellan A, Ferris DK. Crit Rev Immunol. 1988; 8(4):315-39.
Review HIV-1 proteins in infected cells determine the presentation of viral peptides by HLA class I and class II molecules and the nature of the cellular and humoral antiviral immune responses--a review. [Virus Genes. 1994]
Review HIV-1 proteins in infected cells determine the presentation of viral peptides by HLA class I and class II molecules and the nature of the cellular and humoral antiviral immune responses--a review.
Becker Y. Virus Genes. 1994 Jul; 8(3):249-70.

See reviews... See all...

Cited by 49 PubMed Central articles

Review Cellular and viral mechanisms of HIV-1 transmission mediated by dendritic cells. [Adv Exp Med Biol. 2013]
Review Cellular and viral mechanisms of HIV-1 transmission mediated by dendritic cells.
Coleman CM, Gelais CS, Wu L. Adv Exp Med Biol. 2013; 762:109-30.
Fangchinoline inhibits human immunodeficiency virus type 1 replication by interfering with gp160 proteolytic processing. [PLoS One. 2012]
Fangchinoline inhibits human immunodeficiency virus type 1 replication by interfering with gp160 proteolytic processing.
Wan Z, Lu Y, Liao Q, Wu Y, Chen X. PLoS One. 2012; 7(6):e39225. Epub 2012 Jun 13.
Anti-retroviral strategies for AIDS and related diseases. [Can J Infect Dis. 1991]
Anti-retroviral strategies for AIDS and related diseases.
Wainberg MA, Dascal A, Mendelson J. Can J Infect Dis. 1991 Fall; 2(3):121-8.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Inhibition of human immunodeficiency virus syncytium formation and virus replica...
Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.
Proc Natl Acad Sci U S A. 1987 Nov ;84(22):8120-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: