Unusual features of CpG-rich (HTF) islands in the human alpha globin complex: association with non-functional pseudogenes and presence within the 3' portion of the zeta gene

N Fischel-Ghodsian; R D Nicholls; D R Higgs

doi:10.1093/nar/15.22.9215

Unusual features of CpG-rich (HTF) islands in the human alpha globin complex: association with non-functional pseudogenes and presence within the 3' portion of the zeta gene

Nucleic Acids Res. 1987 Nov 25;15(22):9215-25. doi: 10.1093/nar/15.22.9215.

Authors

N Fischel-Ghodsian¹, R D Nicholls, D R Higgs

Affiliation

¹ Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, UK.

Abstract

We have characterised a cluster of CpG rich (HTF) islands in the alpha-globin complex and report here two unusual features: The human embryonic zeta 2-globin gene is associated with an HTF island within its 3' portion rather than at the 5' end. Furthermore at least two non-functional pseudogenes within the cluster (psi zeta 1 and psi alpha 2) are associated with CpG rich islands.

Publication types

Comparative Study

MeSH terms

Animals
Base Sequence
Cytidine Monophosphate / analogs & derivatives
Cytosine
DNA Restriction Enzymes
Dinucleoside Phosphates*
Genes*
Globins / genetics*
Guanine
Guanosine / analogs & derivatives
Humans
Pseudogenes*
Species Specificity

Substances

Dinucleoside Phosphates
Guanosine
cytidylyl-3'-5'-guanosine
Guanine
Cytosine
Globins
DNA Restriction Enzymes
Cytidine Monophosphate