Format

Send to

Choose Destination
See comment in PubMed Commons below
Brain. 1987 Oct;110 ( Pt 5):1131-53.

Clinical and pathological features of diffuse cortical Lewy body disease (Lewy body dementia).

Author information

  • 1Department of Neuropathology, National Hospitals for Nervous Diseases, Maida Vale, London.

Abstract

Four patients with severe dementia and a parkinsonian syndrome are described. Dysphasia, dyscalculia, dyspraxia, visual and verbal memory disturbance and psychosis, usually of depressive type, occurred early in the course of the illness. Pathologically they were characterized by the presence of numerous Lewy bodies throughout both the cerebral cortex and brainstem. Three cases also had severe neurofibrillary tangle change or senile plaques in the neocortex, compatible with Alzheimer's disease, but the cortical tangle distribution did not always match that of the Lewy bodies. This disorder may form part of the spectrum of pathology in Parkinson's disease, where it may be one possible cause of dementia.

PMID:
2823957
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk