Abstract
Patients with inherited or acquired immunodeficiency disorders are vulnerable to a broad spectrum of opportunistic infectious diseases, but a narrow spectrum of malignancies. These malignancies--B-cell lymphomas, Kaposi's sarcomas, and squamous cell carcinomas--are likely due to failure of immune surveillance to recognize virally transformed target cells. The evidence for this hypothesis is substantial regarding Epstein-Barr virus-induced lymphoproliferative lesions in immunodeficient patients.
MeSH terms
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Acquired Immunodeficiency Syndrome / complications
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Acquired Immunodeficiency Syndrome / immunology
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Acquired Immunodeficiency Syndrome / pathology
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Herpesvirus 4, Human / immunology
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Humans
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Immunologic Deficiency Syndromes / complications*
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Immunologic Deficiency Syndromes / immunology
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Immunologic Deficiency Syndromes / pathology
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Immunologic Surveillance
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Neoplasms / etiology*
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Neoplasms / immunology
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Neoplasms / pathology
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Opportunistic Infections / etiology*
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Opportunistic Infections / immunology
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Sarcoma, Kaposi / etiology
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Tumor Virus Infections / etiology