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    J Biol Chem. 1987 Oct 25;262(30):14612-7.

    Isolation of a cDNA encoding the muscle-specific subunit of human phosphoglycerate mutase.

    Source

    H. Houston Merritt Clinical Research Center for Muscular Dystrophy and Related Disorders, Columbia University, College of Physicians & Surgeons, New York, New York 10032.

    Abstract

    We have isolated a full-length cDNA specifying the muscle-specific subunit of human phosphoglycerate mutase (PGAM-M). The cDNA encodes a deduced protein 253 amino acids in length and contains an unusually short (37 nucleotides) 3'-untranslated region. The deduced human PGAM-M protein is clearly related to yeast PGAM and to human diphosphoglycerate mutase. Genomic Southern analysis using the PGAM-M cDNA as a probe implies the presence of a large PGAM gene family in the human genome, while Northern analysis demonstrates tissue-specific transcription of this isoenzyme gene.

    PMID:
    2822696
    [PubMed - indexed for MEDLINE]

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